The Dead End Kids are introduced in their intricate East Side slum, overlooked by the apartments of the rich. Their antics, some funny, some vicious, alternate with subplots: unemployed architect Dave is torn between Drina, sweet but equally poor, and Kay, a rich man's mistress; gangster Baby Face Martin returns to his old neighborhood and finds that nobody is glad to see him. Then violent crime, both juvenile and adult, impacts the neighborhood and its people.

On his uncle's death Sir Henry Baskerville returns from abroad and opens up the ancestral hall on the desolate moors of Devonshire. Holmes uncovers a plot to have Sir Henry murdered by a terrible trained hound. First casting of Rathbone and Bruce as Holmes and Watson.